TFEB and neoplasm: Moreover, TFEB upregulation may contribute to tumour formation in sporadic RCC (Durinck et al, 2015; Gupta et al, 2017), and depletion of TFEB is sufficient to prevent tumorigenesis in xenografts derived from renal tumours in patients with Birt–Hogg–Dubé syndrome (BHDS; Di Malta et al, 2023).