TSC2 and tuberous sclerosis: Moreover, in the renal tumours from mouse models of tuberous sclerosis complex (TSC), the absence of Tsc2 inhibits FLCN and thus promotes RagC/DGTP formation, establishing a non‐canonical means of preventing mTORC1‐mediated phosphorylation of TFEB, thereby driving its nuclear translocation (Alesi et al, 2021).