TFEB and juvenile neuronal ceroid lipofuscinosis: Furthermore, the ability of genistein and 2‐hydroxypropyl‐(beta)‐cyclodextrin to alleviate pathology in mucopolysaccharidoses and Niemann–Pick Type C depends at least partly on TFEB (Moskot et al, 2014; Song et al, 2014), and direct pharmacological activation of TFEB by limiting its Akt‐mediated phosphorylation reduces aggregation of the ceroid lipopigment that typically accumulates in Batten disease (Palmieri et al, 2017).