In fact, in tumours from patients and mouse models BHDS, RCC, PDAC, and melanoma, amplified and hyperactive TFEB transcriptionally induces the expression of RagD, thereby sustaining the proliferation of cancer cells by priming them for efficient lysosomal recruitment and re‐activation of mTORC1 upon refeeding and consequent replenishment of the intracellular amino acid pool (Di Malta et al, 2017). The gene discussed is TFEB; the disease is cancer.