TEK and glioblastoma: Moreover, proangiogenic signaling induced by angiopoietin 2 (ANG2)/TIE2 cytokines contributes to vascular VEGF-dependent angiogenesis and increases microvessel density of the TME as well as vascular permeability, and thus, dual targeting of ANG2 and TIE2 or ANG2 and VEGF extends both the window of normalization and reduces metastatic dissemination in patients with glioblastoma compared with VEGF or ANG2 inhibition alone (39, 59).