Depending on the cell source, IFNγ produced by T cells limits the tumor angiogenesis (54), while IFNγ-expressing ECs upregulate PD-L1 in tumor cells and limit antitumor immunity, which guided that multi-targeting of ANG2, VEGF, and PD-L1 enhanced antitumor responses in transplanted tumor models (57, 60). This evidence concerns the gene CD274 and neoplasm.