The reports of insulin resistance in patients with severe acne (Del Prete et al., 2012; Emiroglu et al., 2015; Nagpal et al., 2016) and the association of acne with diets delivering high glycaemic loads (Adebamowo et al., 2008; Smith et al., 2008a; Melnik, 2015) create a strong basis to examine the role of insulin in SG function. Here, INS is linked to acne.