Enhanced inflammatory sensitivity is also apparent in IUGR skeletal muscle, as hindlimb muscles from IUGR fetal sheep and rats exhibited greater gene expression for TNFR1, the IL-6 receptor (IL6R), and even the TWEAK receptor (Fn14) near term (Cadaret et al., 2019a; Posont et al., 2022). The gene discussed is TNFRSF12A; the disease is fetal growth restriction.