C1S and hyperinsulinemic hypoglycemia, familial, 4: Given that HAE is a rare disease, being able to count on both categories of information, elements that provide more specific data for a more accurate diagnosis that make it possible to estimate hereditary cases from early stages due to C1-INH deficiency qualitatively or quantitatively, or with normal C1 esterase inhibitor, will undoubtedly be key elements for a better understanding and management of this clinical condition.