However, the expression of ECM genes such as mesenchymal collagens Col3a1 and Col1a1 (Figure 7C) as well as EMT markers found in tumorigenic EMT (Latil et al., 2017) or renal fibrosis, including EMT-associated cytoskeleton Vimentin, Fn1 (Figure 7C) and Sparc (Supplementary Figure S6C), were significantly increased in Smarca4cKO tubular cells. The gene discussed is SPARC; the disease is renal fibrosis.