In head and neck squamous cell carcinoma, over half of the patients overexpress HGF which stimulates MET to induce the proliferation of cell cycle genes by activating STAT3 in the TME (Igelmann et al., 2019; Boschert et al., 2020; Raj et al., 2022). This evidence concerns the gene HGF and head and neck squamous cell carcinoma.