In the high-risk group, multiple cancer-related and ECM relative pathways were upregulated, which included pathways in cancer (p < 0.05), the cell cycle (p < 0.05), KRAS signaling up (p < 0.05), adherens junction (p < 0.05), ECM receptor interaction (p < 0.05), and notch signaling (p < 0.05). Here, KRAS is linked to cancer.