TNC and cancer: A previous study has confirmed that MET facilitates stromal rewiring by upregulating tenascin-C (TNC) expression, which interacts with ECM components and is deeply involved in the metastasis of cancer, stimulating the proliferation and restraining the differentiation of CSCs in PC (Jones and Jones, 2000; Orend, 2005; Orend and Chiquet-Ehrismann, 2006; Modica et al., 2021).