We speculate that the excessive activation of GluN2B subunits plays a certain role in the emission of the blue spectrum biophoton component in response to glutamate, because the spectral blueshift was found in synaptosomes and brain slices from AD and VaD animals, while the pre-perfusion of ifenprodil could reverse this change. The gene discussed is GRIN2B; the disease is Alzheimer disease.