Additionally, the pre-perfusion of ifenprodil could reverse the decreased biophotonic activity induced by glutamate, implying that the excessive activation of GluN2B may play a role in the functional decline of glutamatergic synaptosomes, and that such a change may occur in the early stage of AD and VaD and is related to the decline in cognitive function, which has been verified by cognitive assessments performed in this study. Here, GRIN2B is linked to Alzheimer disease.