SLE, systemic lupus erythematosus; APS, antiphospholipid syndrome; IUD, intrauterine device; LNG, levonorgestrel; DMPA, depot medroxyprogesterone acetate; COC, combined oral contraceptive; vaginal ring, combined hormonal vaginal ring; patch, combined hormonal patch; aPL, antiphospholipid antibody. The gene discussed is FASLG; the disease is systemic lupus erythematosus.