Single nucleotide polymorphisms (SNPs) in the immunoregulatory genes (MICArs2596542, CD44rs187115, PDCD1rs 7421861, and rs10204525), superoxide dismutase 2 (SOD2) and patatin-like phospholipase domain containing 3 (PNPLA3) [108,109] may be involved in the development of the HCC [110]. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.