RAS protein activator like 1 (RASAL1), Egl-9 family hypoxia-inducible factor 3 (EGLN3), CUB sushi Multiple domains 1 (CSMD1), cyclin-dependent kinase inhibitor 2A (CDKN2A), BCL6 corepressor like 1 (BCORL1), zinc finger protein 382 (ZNF382) a member of zinc finger family, RUNX family (RUNX3), lysyl oxidase (LOX), RB transcriptional corepressor 1 (RB1), and tumor protein p73 homology to p53, all tumor suppressor genes are downregulated in HCV-related HCC [137]. The gene discussed is CSMD1; the disease is hepatocellular carcinoma.