HBV affects innate immunity by inhibiting IRF-3 nuclear import and development of HCC by activating the PI3K/AKT, p38MAPK, JNK, ERK, NF-kß, WNT ß catenin, hypoxia-inducible factor 1α, Notch, and Hodge pathways [81,82]. This evidence concerns the gene PIK3CA and hepatocellular carcinoma.