Genetically predicted higher levels of GREM1 and CHRDL2 were associated with an increased risk of CRC, while the other 11 proteins (CLSTN3, POLR2F, ADPGK, CSF2RA, CSAG1, STXBP6, CD86, CXADR, FUT3, MMP2, and TIMP2) were negatively associated with CRC risk, suggesting that lower levels of the 11 proteins were associated with a higher risk of CRC. This evidence concerns the gene CXADR and colorectal carcinoma.