CHRDL2 and colorectal carcinoma: In the meta-analysis of these three sources, 11 proteins showed significant associations, and the odds ratio (OR) (95% confidence interval, CI) of CRC per SD increase in genetically predicted levels of protein was 1.12 (1.09–1.15) for GREM1, 1.32 (1.15–1.50) for CHRDL2, whereas 0.29 (0.19–0.44) for CLSTN3, 0.24 (0.15–0.38) for POLR2F, 0.23 (0.14–0.36) for ADPGK, 0.23 (0.14–0.36) for CSF2RA, 0.92 (0.90–0.94) for CSAG1, 0.90 (0.87–0.93) for STXBP6, 0.34 (0.20–0.58) for CD86, 0.83 (0.71–0.96) for CXADR, and 0.92 (0.90–0.95) for FUT3 (Fig. 3).