Collectively, we identified four proteins (GREM1, CLSTN3, CSF2RA, CD86) with the most convincing evidence (tier 1), five proteins with convincing evidence (tier 2), and four proteins with middle convincing evidence (tier 3), among which six (CLSTN3, POLR2F, ADPGK, CSAG1, STXBP6, FUT3) were novel plasma protein makers associated with CRC. This evidence concerns the gene CSF2RA and colorectal carcinoma.