CLSTN3 and colorectal carcinoma: Six of the other 11 proteins (GREM1 and FUT3 with cis pQTL; CLSTN3, CSF2RA, CD86, and ADPGK with trans pQTL) were supported by strong evidence of genetic colocalization (PP4 > 80%) under different priors and windows (Table 1, Additional file 1: Table S9), indicating high probability for a shared causal variant between protein level and CRC risk.