In sensitivity analysis (cis only MR), four of 13 proteins had cis pQTLs, and three (GREM1, CHRDL2, FUT3) of them were still significantly associated with CRC risk (P < 2.70×10−5) based on Wald ratio or IVW method, with a consistent direction with the primary analysis (cis+trans MR). Here, CHRDL2 is linked to colorectal carcinoma.