Given that (i) many of the most important gene variants affecting dementia risk regulate lipid transport and catabolism [64], (ii) structural modelling has proposed a lipid binding function for TMEM106B [65], and (iii) TMEM106B protein levels were correlated with proteins regulating fatty acid and lipid metabolism, we used lipidomic analysis to determine how dementia risk allele rs1990622-A affects lipid composition in the hippocampus of cognitively normal humans. Here, TMEM106B is linked to dementia.