A SNP in the 3’ untranslated region of TMEM106B (rs1990622-A) is associated with increased risk for AD, FTD, Parkinson’s disease, HS-ageing, and LATE [4, 43, 49, 50], and is in perfect linkage disequilibrium with other SNPs in the TMEM106B gene that modify dementia risk (Fig. 3A). The gene discussed is TMEM106B; the disease is Alzheimer disease.