VDAC1 and Familial prostate cancer: In prostate cancer cells, the Drp1-partner MFF was found to interact with the voltage-dependent anion channel-1 (VDAC1) at the OMM, and blocking such interaction led to a collapse of mitochondrial functions with increased MOMP, loss of inner membrane potential, Ca2+ unbalance, bioenergetics defects, and activation of cell death [210].