An article reported that MSCs can promote the development and progression of cancer in various ways; however, MSCs can also participate in the induction and inhibition of cancer progression and metastasis mediated by some signaling pathways such as PI3K/AKT signaling pathway, JAK/STAT signaling pathway, Wnt signaling pathway, Hippo signaling pathway, MYC signaling pathway, and NF-κB signaling pathway [258]. This evidence concerns the gene AKT1 and cancer.