Functional Reelin expression is altered in AD [6, 12, 37], and its protective effects are antagonized by Aβ toxicity [51, 68]. Gene polymorphisms and altered splice variants of the ApoE/Reelin receptors, Apoer2 [36, 39, 82, 84], and Vldlr [82, 88] have been detected in AD patients. This evidence concerns the gene LRP8 and Alzheimer disease.