Seven of these genes are Alzheimer’s disease-related, six are down-regulated with both Apoer2-ICDs (COX7A2L, FZD2, KIF5A, MAP2K2, PSENEN, RAF1) and one with only the Apoer2-ICD[Δ19] (SLC39A9). This evidence concerns the gene PSENEN and early-onset autosomal dominant Alzheimer disease.