Figure 8 recapitulates the proposed antiproliferative and apoptotic action of Amy on HepG2 cells by up-regulation expression of AMPK, HMGB1, Beclin 1, LC3, and ATG5, and down-regulation expression of mTOR/BCL2 genes that were induced by Amy relative to control and simulate the induction of intrinsic and extrinsic apoptosis pathway in the treated liver cancer cell line. This evidence concerns the gene HMGB1 and liver cancer.