ATG5 and liver cancer: Figure 8 recapitulates the proposed antiproliferative and apoptotic action of Amy on HepG2 cells by up-regulation expression of AMPK, HMGB1, Beclin 1, LC3, and ATG5, and down-regulation expression of mTOR/BCL2 genes that were induced by Amy relative to control and simulate the induction of intrinsic and extrinsic apoptosis pathway in the treated liver cancer cell line.