This study primarily evaluated the progression of the different overweight- or obesity-associated comorbidities by investigating the change in hemoglobin A1c (HbA1c), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), and alanine transaminase (ALT) in youth with overweight or obesity during the COVID-19 pandemic. The gene discussed is GPT; the disease is Obesity.