It has recently been reported that in various cancer cells, the CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) protein is associated with the controlled expression for the programed cell apoptosis 1 ligand 1 (PD-L1) protein by two critically important researches (Burr et al., 2017; Mezzadra et al., 2017). This evidence concerns the gene CD274 and cancer.