HLA-C and neoplasm: Therefore, based on available researches, we think there are several perspectives and speculative hypotheses worth considering regarding the specific mechanisms of CMTM6 in regulating tumor immunity: (1) Immune checkpoint modulation: CMTM6 may interact with other immune checkpoint molecules, not only PD-L1, then influencing the balance between immune activation and immune tolerance in the TME; (2) tumor-associated antigen presentation: CMTM6 might play a role in the presentation of tumor-associated antigens by modulating the expression or function of MHC molecules.