Additionally, MAPK signaling related molecules (MAPK1, 14-3-3-gamma, RhoA) and the EGF ligand EFEMP1, which has been shown to activate MAPK signaling in pancreatic adenocarcinomas, were enriched in STM compared to YST/TER [25]. This evidence concerns the gene EFEMP1 and pancreatic adenocarcinoma.