Nevertheless, Li et al.33 examined whether changes in the level of serum fibroblast growth Factor 21 (FGF21) and Sequential Organ Failure Assessment (SOFA) scores could predict the 28-day mortality of ICU patients with sepsis and ARDS, and no significant difference was observed between the FGF21 and SOFA scores. This evidence concerns the gene FGF21 and acute respiratory distress syndrome.