Many researchers have found that RvD1 is important in (a) ameliorating LPS-induced inflammatory diseases62; (b) improving insulin sensitivity by resolving the chronic inflammation that is associated with diabetes and obesity63; and importantly, (c) activating the anti-inflammatory response, partially by the conversion of Mφs from classically-activated (M1 phenotype) to alternatively activated (M2 phenotype) cells14. Here, INS is linked to diabetes mellitus.