Interestingly, under CR that lowers whole-body glucose, the differences in tumor size and number between wild-type PHGDH and PHGDH-T57A groups were diminished, but the differences between wild-type PHGDH and PHGDH-R135W (Fig. 6b) were enlarged, reinforcing that glucose/3-PGA availability controls HCC development. Here, PHGDH is linked to hepatocellular carcinoma.