TP53 and neoplasm: The p53 protein is a master tumor suppressor, playing important roles in DNA repair, cell cycle arrest, cell death, and metabolic control.1–4 The stability and activity of p53 are tightly controlled through a series of posttranslational modifications such as phosphorylation and acetylation.5,6 Distinct patterns of phosphorylation for p53 activation, depending on the types of cells and stresses, have been identified, including phosphorylation of Ser15 and Ser20.