To investigate the contribution made by IL-22 in the regulation of BC fate after PR8 infection, we used IL-22Cre/Cre (IL-22 LOF) and IL-22ra1fl/fl/Shh-Cre (IL-22r cLOF) mice to modulate IL-22 levels and signaling, respectively (Fig. 6A). The gene discussed is SHH; the disease is breast cancer.