IL22 and breast cancer: Interestingly, these roles for IL-22 in regulating PR8-elicited BC in the lung contrast with observations made in other organ systems, such as in the epidermis, where IL-22 promotes fibroproliferative responses associated with wound closure40, and in the intestine, where IL-22 regulates epithelial cell fate and host defense through induction of antimicrobial factors41,42.