In an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis induced by the selective expression of MOG (the epitope of myelin oligodendrocyte glycoprotein in DCs), mice were vaccinated with MOG-encoding N1-methylpseudouridine mRNA after immunization with MOG, and the results showed that they were protected from disease development. The gene discussed is MOG; the disease is multiple sclerosis.