IL1B and COVID-19: FDA-approved disulfiram can suppress pyroptosis through suppression of GSDMD pore formation as well as Cys191/Cys192 covalent modification within for blocking pore formation in cells and animal models, finally suppressing IL-1β generation and pyroptosis.105 Inhibiting pyroptosis enhancers, such as the ACE/Angiotensin II (Ang II) and serine/threonine kinase (ATR) axes, could be another strategy for COVID-19 treatment.