During COVID-19, pro-inflammatory factor levels, including IL-1β, NF-κB, and TNF-α, within the brain increase in cytokine storm, as a result, AQP4 is up-regulated to aggravate brain edema, in addition, such pro-inflammatory factors are also related to ferroptosis machinery.118 SARS-COV-2 infection-induced inflammation can greatly promote IL-6 production. This evidence concerns the gene TNF and COVID-19.