IL6 and COVID-19: NAC partially rescued IL-6-promoted ROS production and ferroptosis of bronchial epithelial cells as well as nanoparticle-mediated ferroptosis of neurons, which partially interprets its roles in treating COVID-19.136,137 Therefore, NAC may be the GSH precursor that can suppress ferroptosis through reinforcing GPX4-GSH-cysteine axis, but not preventing radical propagation directly as the radical scavenging agent.