CASP3 and Zika virus infectious disease: Emricasan is a small molecule pan-caspase inhibitor that is administered orally, which can prevent caspase-3-dependent death of human cortical neural progenitors in the course of Zika virus infection.66 Plassmeyer et al.67 reported that emricasan suppressed the increased caspase-3 expression within samples cultured using plasma obtained from COVID-19 cases.