CFLAR and autoimmune disease: The apoptotic potential of DISC is restrained by c-FLIP, as it hetero-dimerizes with caspase-8 and blocks caspase-8 activation.62 Consequently, using small molecules targeting c-FLIP for activating caspase-8 while inducing extrinsic apoptosis is the critical way for contrasting viral replication.63 Infliximab, the human-mouse chimeric immunoglobin G1 (IgG1) monoclonal antibody (McAb) targeting TNF-α, has been applied in treating various autoimmune diseases.