To investigate the involvement of ABCC1 in mechanisms of Venetoclax resistance in more detail, we treated Cas9-expressing MOLM-13 and MV4-11 AML cells with increasing concentrations of Venetoclax until they displayed stable growth in culture in the presence of 1 μM Venetoclax (Fig. 5E). The gene discussed is ABCC1; the disease is acute myeloid leukemia.