The cytosolic double-stranded DNA (dsDNA) released from necrotic RGCs after an episode of retinal ischemia is a potential DAMP, and the mechanisms underlying the recognition of dsDNA by nucleic acid-sensing cyclic GMP-AMP (cGAMP) synthase (cGAS) in ischemic retinal inflammation have not yet been explored. The gene discussed is CGAS; the disease is retinal ischemia.