IL6R and Disorder of lipid metabolism: We identified other SVs in several other candidate high-altitude adaptation genes (Supplementary Data 8), including PPARA encoding a transcription factor associated with fatty liver disease and lipid metabolism disorder, the apoptosis regulator gene BCL2, the epidermal growth factor receptor gene EGFR, the insulin-like growth factor gene IGF1R which in dogs and mice is found to have an effect on body size, and the cytokine interleukin 6 receptor gene IL6RA. Further research may clarify the role of these genes in hypoxia adaptation.