TGFB1 and myositis disease: If the Th2 cytokine IL-4 overexpressed in myositis seems inversely correlated with the severity of muscular destruction, as evidenced by muscular enzyme levels in the sera [63], anti-inflammatory macrophage cytokines (TGFβ and IL-10) are also highly expressed in myositis and seem to be involved in the pathogenesis [47, 64].