The interstitial void spaces enable facile nutrients, oxygen, and cellular products to exchange with the cell culture medium,[99] resulting in a physiological‐like gradient that stimulates the migration of cancer cells inside the porous scaffold.[99, 100] As opposed to 2D contact guidance along adhesion cues, the 3D scaffolds show that migration of metastatic and non‐metastatic breast cancer cells in confinement has more stringent requirements for the activity of dynein and myosin motors. Here, MYH14 is linked to breast carcinoma.