It is also conceivable that a potential excess of fatty acyl‐CoA levels in the muscle of males/females with obesity or T2D could lead to feedback inhibition of the ACS, either directly or by regulating the activity of transcription factors (Faergeman & Knudsen, 1997), such as PPARα and –γ (Martin et al., 1997). This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.