SERPINE1 and retinal ischemia: Retinal ischemia triggers cellular senescence via the upregulation of classical senescence-associated proteins, such as p53, p16INK4a, and γH2A.X, and multiple SASP marker genes, including matrix-degrading enzyme plasminogen activator inhibitor 1 (Pai1), TGF-β1, IL-6, IL-1β, and vascular endothelial growth factor-α (VEGF-α) [22].