PINK1 and neurodegenerative disease: PTEN-induced kinase 1 (PINK1)/Parkin RBR E3 ubiquitin-protein ligase (PARKIN) signaling-induced mitophagy is one of the best-described forms of selective autophagy, partly because mitophagy dysfunction is linked to various pathologies, including neurodegenerative diseases and age-related ocular diseases [110].