Furthermore, after exposure to glaucoma-related stimuli, high levels of mTOR activity and p62 in RGCs, along with low levels of the autophagy-related proteins ATG12-ATG5 and ATG4 and of the BECN1/Beclin1 and LC3-II/LC3-I ratios, may lead to the impairment of the autophagic flux, thereby accelerating the loss of RGCs [103]. Here, BECN1 is linked to glaucoma.