TFAM and glaucoma: Moreover, it promotes RGC survival by maintaining the mtDNA content and the expression of mitochondrial transcription factor A/oxidative phosphorylation complex IV protein in the retina of a mouse model of glaucoma [161].In addition, oral administration of vitamin B3 or gene therapy aimed at boosting the expression of NAD+ has been shown to be protective in aged mice for glaucoma prevention and intervention [77].