Interestingly, HCC patients with high risk score had a higher gene set score correlated with angiogenesis, DNA repair, EMT, G2M checkpoint, glycolysis, hypoxia, mitotic spindle, IL6-JAK-STAT3 signaling, MTORC1, NOTCH signaling, P53 pathway, and P13K-AKT-mTOR signaling (Fig 10A–10L), indicating that the activation of these biological processes may play a vital role in HCC tumorigenesis and progression. This evidence concerns the gene IL6 and hepatocellular carcinoma.