In our study, we constructed a signature consisting of 12 MRGs (SNRPA, RECQL4, TRIM28, ERCC2, GRWD1, REEP4, PRMT1, PAF1, LAPTM4B, RANBP1, BCAT1, and PTK) which was a promising predictor of the prognosis of HCC. This evidence concerns the gene RECQL4 and hepatocellular carcinoma.