This optimal MRPS was developed using 12 MRGs, and the risk score of each HCC case was calculated using following formula: risk score = 0.5671879 × SNRPAexp + (-0.4282688) ×RECQL4exp + 0.6410663 ×TRIM28exp + (-0.3376426) × ERCC2exp + 0.3590617 × GRWD1exp + 0.4491523 × REEP4exp + (-1.2190593) × PRMT1exp + (-0.3341503) × PAF1exp + 0.2864963 × LAPTM4B exp + 0.3805174 × RANBP1exp+ (-0.3052321) × BCAT1exp + 0.4239179 × PTK7exp. The gene discussed is LAPTM4B; the disease is hepatocellular carcinoma.