As a result, HCC patients with high risk score had a higher gene set score correlated with angiogenesis, DNA repair, EMT, G2M checkpoint, glycolysis, hypoxia, mitotic spindle, IL6-JAK-STAT3 signaling, MTORC1, NOTCH signaling, P53 pathway, and P13K-AKT-mTOR signaling. Here, IL6 is linked to hepatocellular carcinoma.