Recently, it was shown that membrane-bound ACE2 acts as a receptor for SARS-CoV-2, but the possible effects on RAS components [ATII, Ang-(1-7), ACE1, ACE2, AT1, and Mas] and whether ACEi and angiotensin receptor blockers interfere with the mitigation of COVID-19 require further investigation [50-54]. The gene discussed is ACE; the disease is COVID-19.