Interestingly, organoids derived from presorted cells containing a mix of B7H3+ and B7H3NEG cells, representative of intra-tumor heterogeneity, were almost equally sensitive as B7H3+ organoids, perhaps as a result of combined cell death via B7H3+-specific ADC activity and bystander killing effect (Figure 2G, red line). This evidence concerns the gene CD276 and neoplasm.