PAX5 and B-cell acute lymphoblastic leukemia: Human PAX5 also plays a key role in B cell acute lymphoblastic leukemia (B-ALL) as a haploinsufficient tumor suppressor gene (Gu et al., 2019; Mullighan et al., 2007) as well as a partner gene of different oncogenic PAX5 translocations (Coyaud et al., 2010; Nebral et al., 2009).