Whilst our study initially examined relatively young adult male mice in HFD cohorts, the unanticipated observation of hindlimb paralysis, a possible indication of aortic thrombosis, aneurysm or rupture, prompted us to investigate a cohort of regular chow-fed 8 month old female Tβ4-/-; ApoE-/- and age-matched Tβ4+/+; ApoE-/- mice. This evidence concerns the gene APOE and Venous thrombosis.