NRG1 and colon adenocarcinoma: The qRT-PCR results showed that the mRNAs of all CAFRs genes were differentially expressed in COAD tumor tissues and adjacent normal tissues, among which CD36, NRG1 and FGF9 were highly expressed in adjacent normal tissues, whereas TIMP1, TERT, CDKN2A, PCAT6, CYP19A1, IL13, SNAI1, BDNF, GPC1, SERPINH1, AGER, and ENO2 were highly expressed in the tumor tissues (Figure 12A–12O).