FUT8 and pulmonary fibrosis: To explore whether knockout of the FUT8 gene in AECs will rescue AECs from senescence and ameliorate pulmonary fibrosis in vivo, we devised an in vivo assay with alveolar epithelial cell-specific FUT8 conditional knockout (FUT8flox/flox; SftpcCRE, CKO) mice in our previous study and chosen FUT8flox/flox (Fl/Fl) mice as the control.