TGFB1 and pulmonary fibrosis: In addition, because of TGF-β’s pleiotropic involvement in addressing a diverse set of downstream regulators, the mechanism underlying pulmonary fibrosis activation of TGF-β action has been associated with WNT crosstalk [27, 38], however, it has to be seen whether CF can activate the relevant signaling cascade by influencing other proteins such as EGFR to TGF-βR I.