NFE2L2 and acute kidney injury: Moreover, mitochondrial autophagy controls mitochondrial mass and mitigates mitochondrial ROS by degrading damaged mitochondria and inhibiting renal apoptosis [34] As reported, the Nrf2/HO-1 signaling pathway has been proven to function as one of the key molecular mechanisms participating in oxidative stress, inflammatory activity, and damaged mitochondria in AKI mice [35–37].