Yet, clinical failure after conservative surgery has been estimated to range between 0% and 35%.2,7,18 Exposed bone, presence of ischemia and necrotizing soft tissue infection,2 peripheral arterial disease (PAD), higher C-reactive protein on admission (115.9 ± 112 mg/L in case of failure; 47.6 ± 47.5 mg/L in case of remission) and abscess formation18 are factors that have been suggested to be related to clinical failure in conservative surgery. This evidence concerns the gene CRP and peripheral arterial disease.