Yet, clinical failure after conservative surgery has been estimated to range between 0% and 35%.2,7,18 Exposed bone, presence of ischemia and necrotizing soft tissue infection,2 peripheral arterial disease (PAD), higher C-reactive protein on admission (115.9 ± 112 mg/L in case of failure; 47.6 ± 47.5 mg/L in case of remission) and abscess formation18 are factors that have been suggested to be related to clinical failure in conservative surgery. Here, CRP is linked to ischemia.