Additionally, SMN2 mRNA levels have been shown to rapidly return to baseline within 32 h after both single and repeated dosing of splicing‐inducing small molecules such as risdiplam, while the SMN protein continues to increase (Naryshkin et al, 2014), and SMN2 mRNA expression poorly correlates with protein expression in spinal cord samples from human SMA subjects (Ramos et al, 2019). This evidence concerns the gene SMN1 and proximal spinal muscular atrophy.