In order to identify small molecules that selectively modulate SMN2 pre‐mRNA splicing to include exon 7, we performed a cell‐based screen in SMA type II‐patient derived fibroblasts carrying three copies of the SMN2 gene, using a collection of 54 chemical probes from the Structural Genomics Consortium (SGC) collection (https://www.thesgc.org/chemical‐probes) (Scheer et al, 2019; Wu et al, 2019) (Table EV1). The gene discussed is SMN2; the disease is proximal spinal muscular atrophy.