PO: change in BMI SO: change in obesity-related cardiovascular risk factors at 6, 12, and 24 months. Obesity-related cardiovascular risk factors included: waist circumference, SBP, DBP, fasting blood glucose, HbA1C, total CHL, HDL, LDL, triglycerides, and C-reactive protein. The gene discussed is CRP; the disease is obesity disorder.