After adjusting for age, sex, operation level, history of stroke and CHD, anesthesia time, drinking status, intraoperative hypotension, CRP, Hb, fluid and blood transfusion volume, urinary volume, bleeding volume, ASA Physical Status Classification System, and all CHS components, participants who never smoked, exercised frequently, and had normal blood pressure had decreased risk of AKI, with corresponding ORs (95% CI) of 0.66 (0.47, 0.91), 0.73 (0.60, 0.92), and 0.46 (0.28, 0.75), respectively. This evidence concerns the gene GSTM1 and Stroke.