EPO and acute kidney injury: For decades, different therapeutic agents have been investigated for the management of AKI associated with sepsis with disappointing results; the use of agents such as statins [55], erythropoietin [56], steroids [57], alkaline phosphatase [58] and pirfenidone [17] is an important justified effort, and the search for a drug that consistently improves kidney function and potentially decreases the probability of dying continues.