Additionally, suppression of β2-integrin mediated signalling via sialic acid binding Ig-like lectin E (Siglec-E) has been shown to negatively regulate pulmonary neutrophil recruitment in an NADPH oxidase dependent manner (McMillan et al., 2013; McMillan et al., 2014) suggesting mechanisms to limit neutrophil recruitment are impaired in CGD. This evidence concerns the gene FMO5 and chronic granulomatous disease.