HR-LC/MS identified some important phytoconstituents followed by network pharmacology analysis which revealed that 8-hydroxycoumarin, Delsoline, Royleinine, Delsemine B, Herniarin, Aloesin, Talatisamine, Narwedine, Scoparone, and Piperine were the main constituents related to breast cancer targets while Akt1, SRC, EGFR, IL-6, Hsp-90AA1, and ESR-1 were the main breast cancer-related molecular targets. This evidence concerns the gene ESR1 and breast cancer.