By retracing the interaction between macrophages and HSC, we found that Thbs1 was derived from macrophages in the fibrosis model, and communicated with HSCs by interacting with the aVb3 (Itgb3) and a2Bb3 (Itga2b&Itgb3) complex receptors (Figure 3C). Here, ITGB3 is linked to fibrosis.