Thus, our subcluster analysis revealed the presence of at least four phenotypes of HSCs during liver fibrosis, namely myeloid myofibroblasts (HSC0), resting HSCs (HSC1), Clec3b+ HSCs (HSC2), and myofibroblasts with high expression of Acta2 (HSC3). Here, CLEC3B is linked to Hepatic fibrosis.