S100A4 and Hepatic fibrosis: By stimulating proinflammatory cascades by inflammatory gene expressing and profibrogenic cytokine releasing including Il1b, Tnf, Lgals3, S100a6, S100a4, S100a11, and S100a10, Mac1 was characterized as one of the profibrotic contributors during the liver fibrosis progression (Figure S3A).