STAT3 and colon adenocarcinoma: As shown in the radar plot, the expression of STAT3 is negatively correlated with the TMB in BRCA, thyroid cancer, stomach adenocarcinoma (STAD), sarcoma (SARC), PRAD, pancreatic adenocarcinoma (PAAD), lung squamous cell carcinoma, liver hepatocellular carcinoma, and kidney renal papillary cell carcinoma, and positively correlated with thymoma (THYM), LGG, and COAD (Figure 6a, P < 0.05).