The main transduction pathways involved in ACOX1 associated with ccRCC were as follows: epithelial–mesenchymal transition (EMT), myelocytomatosis (MYC)-targets V1 and MYC targets V2 related to proliferation, TNF-α/NF-kB signaling pathway, the P53 pathway, and the apoptotic pathway (Table 3). The gene discussed is TNF; the disease is nonpapillary renal cell carcinoma.