We analyzed the correlation between ACOX1 and the EMT-related genes and found a positive correlation with cadherin 1 (CDH1), CDH2, cyclin-dependent kinase-like 2 (CDK2), and epithelial cell adhesion molecule, and a negative correlation with matrix metalloproteinase MMP9 and vimentin, suggesting that ACOX1 might be regulated by EMT and affect its metastasis in ccRCC. This evidence concerns the gene CDK2 and nonpapillary renal cell carcinoma.