Based on clinical data from ccRCC patients in TCGA, we found that ACOX1 expression was lower in male patients (n = 345) than in female patients (n = 188) (10.49 ± 0.41 vs. 10.57 ± 0.41, P < 0.05). Here, ACOX1 is linked to nonpapillary renal cell carcinoma.